If you have a number of shortcuts you need to access instantly and very regularly this new mouse-oriented shortcut software called Radian might be worth a look.
This tiny program is only 636kb in size will not drain your computer resources and from a simple right click you are able to access favourite applications without having to visit the task bar or Start Menu. Check out the demo video after the jump.
Upon your right click a radial menu appears around your cursor divided into quarter and three rings. Radian allows you to customise ever aspect of the menu from the compartments to the colours. To help you fine your short cuts instantly.
Radian is an open source application and is currently for Windows only. If you fancy a play, you can download it from the Radian website.